The effect of proinflammatory cytokines in Cognitive Behavioral Therapy

نویسندگان

  • Fernanda Pedrotti Moreira
  • Taiane de Azevedo Cardoso
  • Thaíse Campos Mondin
  • Luciano Dias de Mattos Souza
  • Ricardo Silva
  • Karen Jansen
  • Jean Pierre Oses
  • Carolina David Wiener
چکیده

Major depressive disorder (MDD) is a debilitating disorder and its pathophysiology is associated with deregulation of the immune system. We investigated the changes in circulating levels of proinflammatory cytokines (specifically IL-6 and TNF-α) measured by the ELISA kit in two psychotherapeutic interventions for MDD: Narrative Cognitive Therapy (NCT) and Cognitive Behavioral Therapy (CBT). This is a randomized clinical trial including 97 individuals (18 to 29years-old) with MDD. In CBT there was a significant difference in serum levels of IL-6 and TNF-α, therefore indicating that CBT was more effective than NCT on serum levels proinflammatory cytokines.

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عنوان ژورنال:
  • Journal of Neuroimmunology

دوره 285  شماره 

صفحات  -

تاریخ انتشار 2015